益生菌改善了小鼠过敏诱导喘的指标:通过元分析进行系统性审查
Ricardo Augusto Silva1, Maria Julia Brolezzi Nahas1, Sophia de Castro Bremer2
1Food, Nutrition and Basic, Experimental and Clinical Health Research Group, Department of Functional Sciences, Faculty of Medicine, Western São Paulo University (UNOESTE), São Paulo, Brazil.
Journal of the science of food and agriculture
|May 10, 2025
概括
在过敏性喘的临床前模型中,益生菌补充剂显著降低了炎症细胞和关键介质蛋白. 这些发现支持进一步进行喘预防和治疗的临床试验.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏研究 研究过敏
- 微生物组科学 微生物组科学
背景情况:
- 全球过敏性喘患病率正在上升,需要新的治疗策略.
- 目前对过敏性喘的治疗需要补充或替代方法.
- 肠道微生物组和益生菌在调节免疫反应中的作用是一个正在积极研究的领域.
研究的目的:
- 系统地审查和元分析益生菌对过敏喘参数的影响.
- 在由卵素 (OVA),家尘 (HDM) 和OVA+脂聚糖 (LPS) 诱导的临床前模型中评估益生菌的疗效.
主要方法:
- 对8项涉及182只动物的研究进行了系统审查和元分析.
- 数据来源于七个主要的科学数据库 (PubMed,ScienceDirect,科学网,Scielo,Scopus,EMBASE,谷歌学者) 的数据.
- 使用PRISMA指南和Rayyan软件选择的研究,采用特定的关键字和医学主题标题.
主要成果:
- 总和差异性炎症细胞数量的显著减少 (乙酸性细胞,淋巴细胞,巨细胞,中性细胞) (P < 0.05).
- 肺组织度的显著下降 介质素-13 (IL-13) 和介质素-33 (IL-33).
- 益生菌补充剂在动物模型中显示对关键喘指标有缓解作用.
结论:
- 在临床前模型中,益生菌补充剂有效降低了与过敏喘相关的炎症标志物.
- 这些发现为在人类中进行随机临床试验提供了强有力的理由.
- 进一步的研究可以探索用于预防和治疗过敏性喘的益生菌.
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