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Updated: Jun 25, 2026

Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation
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核形最小程度影响纤维类型特定的疾病进展在核膜肌肉病变的小鼠模型中

Eiji Wada1, Nao Susumu1, Yukiko K Hayashi1

  • 1Department of Pathophysiology, Tokyo Medical University, Tokyo, Japan.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|May 10, 2025
PubMed
概括

埃梅里-德莱法斯肌肉发育不良症 (EDMD) 中的核形状异常似乎在疾病进展中起不大作用. 对EDMD模型小鼠的研究表明,改变的核形态并没有显著地驱动纤维类型特异性肌肉衰竭.

关键词:
埃梅里 - 德里法斯肌肉衰竭症埃默林 (Emerine) 是一个非常重要的.层 A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C A/C肌肉纤维是一种肌肉纤维类型.肌肉再生 肌肉再生核的形状 核的形状

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Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...