儿童喘和过敏与加速表观遗传衰老有关
Miriam Leskien1,2,3, Elisabeth Thiering1,4, Zhebin Yu5
1Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Allergy
|May 10, 2025
概括
儿童过敏性疾病与加速表观遗传衰老有关,这是衰老的生物学衡量标准. 这项研究使用了儿科钟表来表明,喘和湿疹等疾病与更快的生物衰老过程有关.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 儿科过敏 儿科过敏
- 衰老研究研究 衰老研究
背景情况:
- 传统的表观遗传衰老时钟在儿童中表现不佳.
- 关于儿童过敏疾病与表观遗传衰老之间的关联的研究有限.
研究的目的:
- 通过使用专门用于儿科的钟来研究过敏疾病与儿童表观遗传衰老加速之间的关联.
- 在独立的队列中验证发现,并在成年人中探索关联.
主要方法:
- 来自德国LISA出生队列研究 (年龄为6岁和10岁) 的DNA甲基化数据的纵向分析.
- 使用经过验证的儿科钟计算的表观遗传年龄 (Wu等人. ) 的情况.
- 线性混合模型和线性模型用于评估与过敏疾病和空气过敏原敏感性的关联;在BAMSE队列和成人KORA F4队列中复制.
主要成果:
- 在LISA队列中,过敏性疾病 (喘,鼻炎,湿疹) 与表观遗传年龄加速 (0.34年) 有意义地相关.
- 没有发现与空气过敏原敏感性有任何关联.
- 在BAMSE中复制显示出与湿疹的反向关联;在成年人 (KORA) 中,花粉热与使用Horvath时钟加速表观遗传年龄有关.
结论:
- 表观遗传年龄加速与儿童过敏疾病的负担有关.
- 研究结果表明,表观遗传衰老可能反映了持续过敏状况的影响.
- 表观遗传衰老加速与非症状的空气过敏原敏感性无关.
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