综合的αβ-T细胞受体谱分析揭示了在DOCK8缺陷患者中独特的CD8+TCR景观

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Ceren Bozkurt1,2, Gökhan Cildir3, Umran Aba1,2

  • 1Can Sucak Research Laboratory for Translational Immunology, Hacettepe University, Ankara, Türkiye.

Allergy
|May 10, 2025
PubMed
概括

细胞动力学分辨器蛋白8 (DOCK8) 缺乏限制了T细胞受体 (TCR) 谱,特别是在CD8+ T细胞中. 这种免疫谱系分析揭示了潜在的自我反应克隆,为DOCK8缺乏病原体提供了洞察力.

关键词:
在 DOCK8 缺陷中.在T细胞受体谱中.自体免疫性是一种自身免疫性.免疫谱的测序 immune repertoire 的测序.

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