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同时使用质子抑制剂预防氧沙胺诱导的外周神经病变:临床回顾性队列研究
Keisuke Mine1,2, Takehiro Kawashiri1, Kohei Mori1,2
1Department of Clinical Pharmacy and Pharmaceutical Care, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
质子抑制剂 (PPI) 可能减少因氧沙胺诱导的周围神经病变 (OIPN) 引起的化疗中止. 这项研究发现,PPI使用与因OIPN而停止氧沙治疗的比例显著降低.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 氧化诱导的周围神经病变 (OIPN) 是一个重要的临床问题,通常需要停止化疗.
- 质子抑制剂 (PPI) 在临床前模型中已经显示出预防OIPN的潜力.
研究的目的:
- 调查PPI的同时使用是否减少了因OIPN而中止的氧沙化疗.
主要方法:
- 一项追溯性研究,涉及1015名接受氧沙治疗的患者.
- 两个队列的比较:使用PPI的人与不使用PPI的人.
- 主要结局:由于OIPN而停止使用氧沙,使用卡普兰-梅尔曲线,日志排名测试和Cox比例危险分析进行分析,并应用倾向性得分匹配.
主要成果:
- 接受PPI的患者由于OIPN而停止使用牛利的比例明显较低 (p=0.0264).
- 考克斯分析表明,PPI使用是减少戒断的因素 (调整HR=0.568,p=0.0269).
- 后倾向性得分匹配分析证实,PPI使用显著减少了与OIPN相关的中止 (p=0.0081;调整HR=0.478,p=0.0096).
结论:
- 同时使用PPI似乎是防止OIPN驱动的氧沙断药的保护因素.
- 调查结果表明,PPI可能是管理oxaliplatin治疗的有价值的辅助剂,以减轻神经病变相关的治疗中断.
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