女性生殖因素和牙周炎之间的因果关系:来自孟德尔随机化研究的证据
Yichen Xiong1, Binjie Liu1,2, Wenjie Li1,3
1Xiangya School of Stomatology, Hunan Engineering Research Center for Oral Digital Intelligence and Personalized Medicine, Hunan Key Laboratory of Oral Health Research, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Central South University, Academician Workstation for Oral-maxillofacial and Regenerative Medicine, Changsha, 410000, China.
Clinical oral investigations
|May 10, 2025
概括
较晚的初潮年龄和第一次分娩增加了慢性牙周炎的风险. 骨矿物质密度可能调解了初潮年龄和牙周炎之间的联系,这表明了女性的新预防策略.
科学领域:
- 生殖健康 生殖健康
- 牙周病学 牙周病学
- 遗传流行病学遗传流行病学
背景情况:
- 牙周炎是一种常见的口腔感染,具有全身影响.
- 女性生殖因子有时与牙周炎有关,但因果证据有限.
- 了解这些联系可以为有针对性的预防策略提供信息.
研究的目的:
- 研究女性生殖因素与慢性牙周炎之间的因果关系.
- 在这种关联中识别潜在的介导因素,如骨矿物质密度.
- 使用孟德尔随机化探索潜在的反向因果关系.
主要方法:
- 利用全基因组关联研究 (GWAS) 总结统计数据来识别仪器变量 (SNP).
- 采用单变门德尔随机化 (UVMR) 来评估生殖因素和牙周炎之间的因果关系.
- 进行了双步门德尔随机化 (Two-Step MR) 进行中介分析和反向MR进行反向因果关系.
主要成果:
- 较晚的初潮年龄 (β=0.1328) 和第一个出生年龄 (β=0.1222) 显示出与慢性牙周炎的积极因果关系.
- 调解分析表明,脚骨矿物质密度 (BMD) 调解了初潮年龄和慢性牙周炎之间的关系.
- 没有发现有意义的反向因果关系.
结论:
- 初潮的年龄和第一次分娩的年龄与慢性牙周炎的风险增加有因果关系.
- 较晚开始的初潮和第一次分娩可能表明女性对牙周炎的易感性更高.
- 需要进一步的研究来阐明这些因果关系背后的确切机制,并为临床实践提供信息.
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