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Updated: Jul 18, 2026

Murine Model of CD40-activation of B cells
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Murine Model of CD40-activation of B cells

Published on: March 5, 2010

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对DuoBody®-CD40x4-1BB (GEN1042/BNT312) 的剂量选择使用mPBPK/RO模型利用临床前和临床数据

Gaurav Bajaj1, Dmitry Shchelokov2, Oleg Demin2

  • 1Genmab, Plainsboro, New Jersey, USA.

Clinical pharmacology and therapeutics
|May 10, 2025
PubMed
概括

优化双特异性抗体 (bsAbs) 需要了解三分子复合体 (三分子) 的形成. 一种新型模型在体内预测了bsAb三元体水平,有助于选择GEN1042,CD40x4-1BB双特异抗体的剂量,以增强抗瘤免疫力.

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