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人类母乳中的菌体多样性:系统性审查
Yanping Guo1, Ying Liu1, Songzhou Xu1
1Department of Pediatrics, Peking University Shenzhen Hospital, No.1120 Lianhua Road, Futian District, Shenzhen, Guangdong, China.
European journal of pediatrics
|May 10, 2025
概括
母乳含有丰富的菌体,这些菌体塑造婴儿的肠道微生物. 这些病毒从母亲传播给婴儿,影响早期发育.
科学领域:
- 微生物学 微生物学
- 病毒学 病毒学
- 婴儿健康 婴儿健康
背景情况:
- 人类母乳是各种微生物的丰富来源,包括细菌菌体,对于建立婴儿肠道微生物组至关重要.
- 菌体是感染细菌的病毒,在宿主内的细菌群体调节中发挥关键作用.
研究的目的:
- 审查和综合当前对母乳中细菌菌体的知识.
- 了解牛奶菌体的组成和传播及其对婴儿肠道微生物群的影响.
主要方法:
- 通过使用PubMed,科学网,科克兰图书馆和EMBASE等数据库进行了系统的文献审查.
- 纳入标准适用于635个记录,最终选择了5项涉及182名女性和251个样本的研究.
- 用一个检查表来评估所包含的研究中的偏差风险.
主要成果:
- 在人乳中发现了七个细菌菌体家族 (Herelleviridae,Myoviridae,Podoviridae,Siphoviridae,Caudoviridales,Microviridae,Inoviridae) 的细菌体.
- 细菌菌体的丰富程度在哺乳期各个阶段都不同,并且通过母乳养从母亲向婴儿垂直传播.
- 由于研究有限和方法差异,无法确定影响细菌丰度的孕产妇和婴儿因素.
结论:
- 人类牛奶含有大量的菌体,它们与特定的细菌宿主结合,有助于婴儿肠道微生物组的垂直传播和塑造.
- 需要对母婴对进行进一步的纵向研究,以阐明牛奶菌体对婴儿发育的精确组成和功能影响.
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