体重指数和癌症存活率:对队列研究的元分析
Lu Li1, Molian Tang1, Shiyi Zhong1
1Department of Clinical Nutrition, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
概括
体重不足的癌症患者面临着更糟糕的整体存活率 (OS). 然而,超重个体显示出生存益处,而肥胖在此元分析中没有显著影响OS.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 体重指数 (BMI) 是营养状况的一个关键指标.
- 癌症患者的BMI和整体存活率 (OS) 之间的关系需要全面评估.
- 目前关于BMI对癌症预后的影响的证据各不相同.
研究的目的:
- 进行一项元分析,评估癌症患者的身体质量指数 (BMI) 和整体存活率 (OS) 之间的关联.
- 综合最近的队列研究的发现,以提供对这种关系的可靠估计.
- 探索体重不足,超重和肥胖对癌症存活率的差异影响.
主要方法:
- 在PubMed,EMBASE,CNKI和万芳图书馆的系统文献搜索 (2019年1月 - 2024年6月).
- 包括与成人癌症患者 (≥18岁) 的队列研究,≥12个月的随访,以及可用的BMI和OS数据.
- 使用固定和随机效应模型进行元分析,以计算OS的危险比率 (HR),BMI根据WHO和中国标准进行分类.
主要成果:
- 包括36项研究,涉及123913名癌症患者;中位数随访时间为41.3个月.
- 体重不足的癌症患者的生存状况明显恶化 (HR=1.43,95% CI:1.30-1.56).
- 超重患者表现出适度有利的生存状况 (HR=0.92,95% CI:0.86-0.99),而肥胖没有显著的关联 (HR=0.95,95% CI:0.90-1.01).
结论:
- 体重不足状态是癌症患者整体存活率较低的重要预测因素.
- 超重,但不是肥胖,与癌症患者中适度改善的OS有关.
- 这些发现强调了BMI在癌症预后和生存结果中的复杂作用.
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