Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genetic Screens02:46

Genetic Screens

4.6K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
4.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Nonparametric testing methods based on relative effect in non-inferiority clinical trial with multiple experimental drugs.

Journal of biopharmaceutical statistics·2026
Same author

Selective and direct hydrogen generation from mixed plastic waste via alkaline thermal treatment with inherent carbon storage.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same authorSame journal

Molecular dosimetry of DNA adducts in mice exposed to ethylene oxide.

Toxicological sciences : an official journal of the Society of Toxicology·2026
Same author

Molecular dosimetry of hemoglobin adducts in mice exposed to ethylene oxide.

Archives of toxicology·2026
Same author

High-Throughput Suspect Screening Reveals Widespread Pesticide Exposure in Early Childhood.

Environment & health (Washington, D.C.)·2026
Same author

Luteolin from Lonicera japonica Thunb. restores GLUT4-mediated glucose uptake via PI3K/Akt signaling in insulin resistance.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026

相关实验视频

Updated: May 5, 2026

Comprehensive Assessment of Germline Chemical Toxicity Using the Nematode Caenorhabditis elegans
10:55

Comprehensive Assessment of Germline Chemical Toxicity Using the Nematode Caenorhabditis elegans

Published on: February 22, 2015

8.0K

识别影响神经发育的环境化学物质,使用基于随机混合的选方法.

Wenxin Hu1,2, Lei Xing1,2, Jieun Park1,3

  • 1UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Toxicological sciences : an official journal of the Society of Toxicology
|May 10, 2025
PubMed
概括

环境中的化学物质可能会损害大脑发育. 这项研究发现, perfluorooctanoic acid (PFOA) 进入胚胎大脑,减少大脑重量,并扰乱神经细胞发育,增加神经发育障碍的风险.

关键词:
神经发育性毒性 神经发育性毒性这就是PFOA的PFOA.从母亲转移到母亲转移

更多相关视频

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays
08:28

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

5.9K
Author Spotlight: High-Throughput Toxicity Screening Using Zebrafish Embryo Startle Response Assay
06:25

Author Spotlight: High-Throughput Toxicity Screening Using Zebrafish Embryo Startle Response Assay

Published on: January 12, 2024

1.3K

相关实验视频

Last Updated: May 5, 2026

Comprehensive Assessment of Germline Chemical Toxicity Using the Nematode Caenorhabditis elegans
10:55

Comprehensive Assessment of Germline Chemical Toxicity Using the Nematode Caenorhabditis elegans

Published on: February 22, 2015

8.0K
Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays
08:28

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

5.9K
Author Spotlight: High-Throughput Toxicity Screening Using Zebrafish Embryo Startle Response Assay
06:25

Author Spotlight: High-Throughput Toxicity Screening Using Zebrafish Embryo Startle Response Assay

Published on: January 12, 2024

1.3K

科学领域:

  • 环境健康 环境健康
  • 神经发育毒理学 神经发育毒理学
  • 发育神经科学的发展神经科学.

背景情况:

  • 环境暴露与神经发育障碍有关.
  • 在体外查中确定了用于体外测试的化学物质.
  • 了解化学物质对发育中的大脑的影响至关重要.

研究的目的:

  • 为了确定影响小鼠神经发育终点的环境化学混合物.
  • 为了确定哪些特定的化学物质穿过胎盘屏障进入发育中的大脑.
  • 为了阐明确定化学物质的神经毒性的细胞机制.

主要方法:

  • 在怀孕小鼠体内测试复杂混合物中的47种环境化学物质.
  • 测量胚胎身体,大脑和胎盘重量.
  • 质谱测量检测胚胎大脑中化学物质的存在.
  • 单核RNA测序用于分析发育中的大脑中的细胞和分子变化.

主要成果:

  • 包括 perfluorooctanoic acid (PFOA) 在内的三种化学物质进入了胚胎大脑,并减少了大脑的重量.
  • 孕期PFOA暴露改变了神经前体细胞的增殖和神经元的分化.
  • 在雄性和雌性小鼠中,PFOA扰乱了神经前细胞中的细胞循环.

结论:

  • 环境化学物质可以显著影响体内神经发育过程.
  • PFOA被确定为一种神经毒剂,影响胚胎大脑发育和细胞机制.
  • 单核RNA测序是了解神经毒性机制的宝贵工具.