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口服管理改善了血液形成干细胞移植患者的结果

Mutsuko Moriwaki¹, Mikayo Toba¹, Makiko Takizawa²

¹Quality Management Center, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan.

International dental journal

|May 10, 2025

概括

对全源造血干细胞移植 (HSCT) 患者实施口腔健康管理可以显著减少抗生素和麻醉剂的使用. 协调牙科和医疗护理对于改善HSCT患者的治疗结果和安全至关重要.

科学领域:

血液学血液学血液学
传染性疾病传染性疾病
口腔医学是指口腔医学.

背景情况:

口腔细菌在输血干细胞移植 (HSCT) 后的血液感染中发挥作用.
口腔卫生管理对HSCT结果的影响需要进一步研究.

研究的目的:

研究口腔健康管理对接受HSCT的患者的影响.
探索口腔健康管理和医疗保健提供系统之间的关系.

主要方法:

一项对12248名年龄大于16岁的患者进行回顾性研究,这些患者在日本急症医院接受了HSCT (2018年4月-2022年3月).
患者被分为自主和异性HSCT组.
多变量分析评估了HSCT期间口服管理对抗生素使用,麻醉剂注射和死亡率的影响.

主要成果:

对于异种性高血压瘤患者,口服治疗与抗生素使用 (2.66 DDD在14天内,6.74 DDD在30天内) 和广泛抗生素使用 (2.79 DDD在30天内) 的显著减少有关.
口服也导致了麻醉品使用的减少 (0.34 DDD在14天内,0.70 DDD在30天内).
在自身的HSCT患者中,没有观察到口服管理的显著影响. 对于无关的HSCT,医院认证标准的提高与口服管理的实施增加有关.

结论:

优化口腔环境的全源性HSCT患者有助于预防感染,提高预期寿命,并减轻疼痛.
涉及牙科和医疗团队的综合护理模式对于提供安全,个性化和高质量的HSCT患者结果至关重要.

关键词:

抗生素抗生素是一种抗生素.牙卫生牙卫生造血干细胞移植造血干细胞移植住院死亡率住院死亡率麻醉剂是一种麻醉剂.口服管理的口服管理.

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