通过辅助生殖技术怀孕的双胞胎中长期的胃肠道疾病
Amir Snir1, Tamar Wainstock2, Gil Gutvirtz1
1The Obstetrics and Gynecology Division, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
概括
通过辅助生殖技术 (ART) 怀孕的双胞胎患有长期胃肠道 (GI) 疾病的风险更高. 这一发现突显了ART双胞胎的潜在健康问题,强调了进一步研究GI健康结果的必要性.
科学领域:
- 生殖医学 生殖医学
- 儿科胃肠病学 儿科胃肠病学
- 公共卫生 公共卫生
背景情况:
- 辅助生殖技术 (ART) 增加了多胎妊娠,影响了后代的健康.
- 虽然对ART单生子进行了充分研究,但对ART双生子的长期健康结果的了解较少.
- 胃肠道 (GI) 疾病是对后代健康的重大关注.
研究的目的:
- 调查ART怀孕双胞胎怀孕与后代的长期胃肠道疾病之间的关联.
- 通过体外受精 (IVF) 或排卵诱导 (OI) 怀孕的双胞胎的胃肠道病率与自发怀孕的双胞胎病率进行比较.
主要方法:
- 双胞胎分娩的基于人口的队列研究 (1991-2021年).
- 在ART怀孕的双胞胎 (IVF,OI) 和自发怀孕的双胞胎之间,对GI发病率 (用ICD-9码定义) 的比较.
- 用卡普兰-梅尔曲线和考克斯比例危险模型进行分析.
主要成果:
- 在双胞胎中,ART与显著更高的整体肠道疾病率有关 (34.9%的试管婴儿,34.3%的OI与27.0%的自发性).
- 在ART怀孕的双胞胎中,随着时间的推移,胃肠道疾病的累积发病率上升.
- 在双胞胎怀孕中使用ART是长期胃肠道疾病的独立风险因素 (IVF的aHR: 1.42,OI: 1.38).
结论:
- 与自发怀孕的双胞胎相比,通过ART怀孕的双胞胎表现出长期胃肠道疾病的风险增加.
- 在调整混因子后,这种关联仍然存在.
- 围产期并发症,如早产和剖腹产,可能部分介于增加的风险.
关键词:
辅助生殖技术 (ART) 是一种辅助生殖技术.结肠疾病,表观遗传修饰胃肠肠疾病 胃肠肠疾病胃肠道疾病发生率在体外受精 (IVF)排卵诱导 (OI) 是指产卵的诱导.过早分娩 过早分娩是什么他们是双胞胎,双胞胎.更多相关视频
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