灵贵州可以通过IL-33/ST2通路调节巨细胞IL-6分泌,从而抑制肺高血压
Zhengwei Dong1, Zhifeng Xue2, Min Zhang1
1The First Affiliated Hospital of Henan University of CM, Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, Zhengzhou 450000, China.
概括
在Lingguizhugan中出了.
科学领域:
- 药理学和中国传统医学
- 心血管研究研究心血管研究
- 免疫学 免疫学 免疫学
背景情况:
- 肺高血压 (PH) 是一种严重的疾病,治疗机制尚不清楚.
- 灵贵州 (Lingguizhugan decoction,简称LGZG) 是一种传统的中国草药配方,用于治疗PH.
- 在治疗PH时LGZG的活性成分和精确机制需要阐明.
研究的目的:
- 评估LGZG在肺高血压治疗中的疗效.
- 为了确定LGZG.G.内的活性成分.
- 阐明LGZG在PH中的作用的潜在分子机制.
主要方法:
- 使用转录组学和细胞因子分析来表征PH患者的表型.
- 通过UPLC-Q-TOF-MS识别了活性LGZG成分 (PCAG).
- 利用单甲素诱导的PH模型 (体内) 和细胞培养 (体内) 来评估LGZG的作用和机制,重点关注IL-33/ST2通路.
主要成果:
- 在PH患者中,炎症标志物和IL-6水平升高.
- 确定了LGZG的活性成分 - - 酸B,酸,阿特拉提利诺利德I和糖素 (PCAG).
- 在PH模型中,PCAG抑制了IL-33/ST2通路,降低了巨细胞极化,抑制了IL-6分泌,并减轻了光滑肌肉细胞切换.
结论:
- 鉴定出LGZG的活性成分PCAG,显示出对PH的治疗潜力.
- PCAG通过抑制IL-33/ST2通路而起作用,从而防止巨细胞的两极分化和IL-6的分泌.
- 这种机制表明PCAG可以通过调节炎症反应和血管重塑来阻碍PH的进展.
相关概念视频
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
162
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
162
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
138
Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
138
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
149
Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
149
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
145
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
145
Pulmonary Hypertension: Classification and Pathogenesis
160
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
160


