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在急性一氧化碳中毒中异常的半球间静止状态功能连接和体微观结构

Mingyue Ma¹, Yu Shang², Xiaoying Lin³

¹Department of Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China; Department of Radiology, the Affiliated Xi'an Central Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Brain research bulletin

|May 10, 2025

概括

急性一氧化碳中毒 (ACOP) 通过破坏半球间连接来损害认知功能. 这项研究揭示了ACOP患者体 (CC) 损伤会影响大脑的通信,导致认知缺陷.

科学领域:

神经科学是一个神经科学.
放射学放射学是一门学科.
毒理学毒理学毒理学

背景情况:

急性一氧化碳中毒 (ACOP) 是一个全球性的健康问题,经常导致认知障碍.
患有ACOP的患者经常表现出功能连接和体 (CC) 退化受损.
ACOP对半球间连接的确切影响及其与认知缺陷的关系需要进一步研究.

研究的目的:

在ACOP患者中调查半球间连接和CC白质微观结构的变化.
在ACOP中探索CC完整性,半球间连接性和认知障碍之间的关系.
阐明ACOP认知缺陷背后的神经生物学机制.

主要方法:

多模式磁共振成像 (MRI) 用于评估30名ACOP患者和28名健康对照 (HC).
分析了voxel-mirrored homotopic connectivity (VMHC) 和CC白物质微观结构 (分数异位性).这些分析结果是:
用格拉斯哥昏迷表 (GCS) 和蒙特利尔认知评估基础 (MoCA-B) 评估认知功能.

主要成果:

与HC相比,ACOP患者在额头,头顶和部区域呈现了减少的VMHC.
在ACOP患者的CC子区域 (膝盖,身体,) 中观察到分数异质性降低.
下叶的VMHC与GCS分数呈正相关,下叶和中圈的VMHC与MoCA-B分数呈正相关.

结论:

改变的半球间连接,特别是减少的VMHC,是ACOP的一个关键特征.
在ACOP患者中,CC白质完整性受到损害,导致认知障碍.
半球间连接性变化调解了CC完整性对ACOP认知缺陷的影响,为神经生物学机制提供了洞察力.

关键词:

这是一种急性一氧化碳中毒.认知障碍认知障碍是一种认知障碍.体 (corpus callosum) 是一个体.静止状态功能磁共振成像技术沃克塞尔镜像同位素连接 Voxel 镜像同位素连接

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