针对结肠特异性药物输送的定制生物聚合物囊:一个3D打印的前景
Jan Muselík1, Alena Komersová2, Jan Elbl1
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Masaryk University, Palackého tř. 1, 612 00 Brno, Czech Republic.
Journal of pharmaceutical sciences
|May 10, 2025
概括
这项研究开发了使用热挤出和化沉积建模的3D打印囊,用于结肠药物输送. 这种新的囊利用多糖为时间和微生物群触发的释放,有效地准结肠.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 在医学中使用3D打印.
背景情况:
- 结肠药物输送系统 (CDDS) 对于治疗结肠疾病至关重要.
- 传统的CDDS通常面临着药物过早释放和可变疗效的挑战.
- 3D打印为先进的药物输送平台提供了新的制造可能性.
研究的目的:
- 开发使用3D打印技术的结肠特异性药物输送系统 (CDDS).
- 创建具有多个释放机制 (时间触发和微生物群触发) 的囊.
- 评估开发的囊的物理化学特性,稳定性和体内性能.
主要方法:
- 采用了热挤出 (HME) 和沉积建模 (FDM) 3D打印技术.
- 基于基甲基纤维素 (HPMC) 的囊配制了各种多糖.
- 在体外 (分解,溶解,稳定性) 和体内 (人类唾液,小猪X射线) 进行了研究.
主要成果:
- 确定了HPMC和果果果 (80:20重量%) 的最佳囊成分.
- 3D打印的囊表现出适当的物理化学特性,延迟时间和稳定性.
- 在上部消化道中实现了最小的药物释放 (<5%),由微生物群触发的加速结肠释放.
结论:
- 成功开发了一种3D打印的结肠特异性药物输送系统.
- 该系统展示了向结肠提供向药物的潜力,提供了改善的治疗结果.
- 这种方法对治疗各种需要结肠药物输送的肠道疾病充满希望.
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