基于微生物群的疗法作为自闭症谱系障碍的新目标:系统审查和元分析
Lucas Hassib1, Alexandre Kanashiro2, João Francisco Cordeiro Pedrazzi3
1Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil; Oswaldo Cruz Foundation, Institute Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
概括
基于微生物群的干预措施有望改善自闭症谱系障碍 (ASD) 行为,便微生物群移植 (FMT) 和益生菌混合物特别有效. 需要进一步的研究来证实这些发现,并指导临床使用.
科学领域:
- 神经科学和肠道微生物组研究
- 儿科行为健康 儿科行为健康
背景情况:
- 自闭症谱系障碍 (ASD) 是一种神经发育状况,在社交互动和沟通方面存在缺陷.
- 肠-大脑轴与ASD病理生理学有关,这表明针对微生物群的干预可能是有益的.
- 目前关于这些干预措施对ASD行为症状的有效性的证据缺乏共识.
研究的目的:
- 系统地审查和元分析各种基于微生物群的干预措施对ASD个体行为结果的影响.
- 具体评估对社会运作的影响.
- 评估包括协生菌,益生菌,益生菌和便微生物群移植 (FMT) 在内的干预措施.
主要方法:
- 20项研究的系统综述和元分析 (16项随机对照试验,4项开放标签).
- 纳入标准侧重于基于微生物群的干预措施和ASD行为结果.
- 普罗斯佩罗的注册号码是:CRD42023494067.7. 这是一个很好的方法.
主要成果:
- 观察到与ASD相关的行为症状有统计学意义的,小但临床相关的改善 (Hedges' g = 0.47).
- 便微生物群移植 (FMT) 和益生菌混合物展示了最实质性的积极影响.
- 在研究中发现了中等的异质性;临床前证据支持神经,免疫和代谢途径的参与.
结论:
- 基于微生物群的疗法,特别是FMT和多菌株益生菌,是改善ASD行为症状的有希望的,耐受性良好的策略.
- 进一步进行高质量的随机对照试验,特别是针对FMT,对于验证发现和为临床实践提供信息至关重要.
- 这些结果为未来研究改进干预和理解潜在机制提供了基础.
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