TNotch1

Jiawen Lu1, Xiuhua Xue2, Haitao Wang3

  • 1Beijing Key Laboratory of Gene Resource and Molecular Development, Beijing Normal University, Beijing, China.

PubMed
概括

在T细胞急性淋巴细胞白血病 (T-ALL) 的发展中,Notch1信号传递至关重要. 虽然准Notch1是有希望的,但其在早期T细胞前体ALL (ETP-ALL) 中的作用需要进一步研究以获得有效的治疗方法.

相关概念视频

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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T Cell Activation and Clonal Selection

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Naive T cells that have not yet encountered an antigen express two primary CD...
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Abnormal Proliferation02:23

Abnormal Proliferation

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The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

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