在医院使用的儿科螺旋诺拉克口服悬浮剂中评估剂量准确性和散质量
Roxanne Desquines1, Romain Gallissot2, Caroline Viard1
1University Hospital Centre Toulouse, Department of Pharmacy, France.
概括
针对儿科心脏病患者的复合螺旋拉克悬浮剂由于同质性差,显示剂量不准确. 即使在接受教育之后,显著的变化和剂量不足仍然存在,这突显了改善儿科配方的必要性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 儿科重症监护中心儿童重症监护中心
- 制药科学 制药科学
背景情况:
- 复合口服螺旋诺拉克悬浮剂对于儿科心脏病患者至关重要.
- 螺旋乳的水溶性差导致沉积,影响剂量准确性和均性.
- 准确的剂量在新生儿重症监护室 (NICU) 和儿科重症监护室 (PICU) 中至关重要.
研究的目的:
- 在儿科重症监护机构评估复合螺旋诺拉克口服悬浮剂的剂量准确性.
- 评估教育干预对悬浮剂制备的影响.
- 确定在实现剂量准确性和均性方面存在的持续挑战.
主要方法:
- 预期在2020年和2022年从NICU和PICU收集和分析斯皮罗诺拉克悬浮样本.
- 使用经过验证的高性能液体染色学与紫外线检测 (HPLC/UV) 方法进行分析.
- 在采样期间之间实施了关于悬浮制备的教育干预措施.
主要成果:
- 2020年,只有28%的NICU和0%的PICU样本达到目标剂量,PICU的变异性更高.
- 在2022年的教育干预之后,有所改善,但剂量不足和变化仍然很大.
- 尽管采取了干预措施,但维持悬浮液均性和实现准确剂量的挑战仍然存在.
结论:
- 复合螺旋诺拉顿悬浮剂在儿科重症监护中存在持续的剂量准确性和同质性挑战.
- 教育干预措施在解决与螺旋诺拉克悬浮制剂相关的问题上表现出有限的成功.
- 开发一种更稳定的儿科配方对于确保患者安全和治疗疗效至关重要.
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