乳腺癌放射治疗后的心血管发病率和死亡率:系统性审查和元分析
Meng-Xi Yang1, Jie-Ke Liu1, He-Ping Deng1
1Department of Radiology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Heart (British Cardiac Society)
|May 10, 2025
概括
乳腺癌放射治疗增加了心力衰竭的风险. 左侧辐射和较高的心脏剂量增加了风险,尽管新的技术可能会改善结果.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
背景情况:
- 乳腺癌的放射治疗可能会导致心脏损伤.
- 由于乳腺癌放射治疗导致的心脏病发和死亡的确切风险尚未得到充分确立.
研究的目的:
- 在接受放射治疗的乳腺癌患者中确定心血管风险的危险比率 (HR).
- 基于放射治疗的侧向性来比较心脏风险.
- 评估心脏辐射剂量与心脏发病率之间的关联.
主要方法:
- 在主要数据库 (MEDLINE,EMBASE,Cochrane图书馆) 进行了系统的文献搜索.
- 随机效应元分析被用来从31项研究 (610,690名参与者) 中汇集HR和95%CI.
- 进行了子组分析和出版偏差测试.
主要成果:
- 放射治疗显著增加了心力衰竭风险 (HR: 1.37).
- 左侧放射治疗与较高的冠状动脉疾病风险有关 (HR: 1.11).
- 在平均心脏辐射剂量和心脏病发病率 (HR:1.12) 之间发现了线性相关性.
结论:
- 乳腺癌放射治疗与心血管不良事件的增加有关,直接与心脏辐射剂量有关.
- 预计辐射技术的进步将改善长期的心血管结果.
相关概念视频
Radiological Investigation III: Pulmonary Angiogram and PET Scan
73
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
73
Biological Effects of Radiation
15.0K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
15.0K
Imaging Studies for Cardiovascular System III: X-Ray
110
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
110
Imaging Studies for Cardiovascular System I:Echocardiography
267
Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
267
Cancer Survival Analysis
301
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
301
Exercise and Cardiovascular Response
650
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
650


