晚些时候被诊断为自闭症的婴儿的大脑形态测量与后来的语言技能有关
Luke E Moraglia1, Bernadette Weigman1, Hervé Abdi1
1Department of Psychology, The University of Texas at Dallas, Richardson, Texas, USA.
Human brain mapping
|May 10, 2025
概括
婴儿大脑结构,特别是左下额头的表面积,与被诊断患有自闭症谱系障碍 (ASD) 的儿童以后的语言能力有关. 这一发现支持一种全脑方法来理解ASD早期神经发育.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 遗传学 遗传学 是一个
背景情况:
- 自闭症谱系障碍 (ASD) 的特点是早期的社会和语言差异.
- 婴儿大脑发育对于理解神经发育障碍至关重要.
- 婴儿-兄弟姐妹设计对于研究ASD的遗传和环境影响是有价值的.
研究的目的:
- 研究婴儿大脑形态测量与生命前两年的语言能力之间的关联.
- 探索后来被诊断患有自闭症的婴儿与对照组之间脑语言关联的差异.
- 通过全脑方法检查早期神经发育轨迹.
主要方法:
- 使用婴儿兄弟姐妹设计,具有高概率 (HL) 和低概率 (LL) 组.
- 在6个月和12个月时通过MRI测量皮质厚度和表面积.
- 在24个月以标准化测试的方式评估表达式和感受性语言.
- 采用部分最小方程相关性分析来检查大脑与行为之间的关系.
主要成果:
- 在高概率自闭症谱系障碍 (HL-ASD) 组中,在左下额头带表面积和24个月的语言能力之间发现了负相关性.
- 超出典型的成人语言网络的大脑区域与HL-ASD婴儿的语言发育有关.
- 表面积和皮层厚度表现出明显的发育关联,表面积的负相关性和6个月厚度的积极相关性.
结论:
- 早期的大脑形态测量,特别是在下额头环中,与婴儿的语言发展有关,这些婴儿后来接受了自闭症谱系障碍 (ASD) 诊断.
- 这些发现支持互动专业化理论,强调婴儿大脑发育的动态性质.
- 整个大脑的方法对于全面了解ASD早期大脑行为关联至关重要.
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