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Updated: May 15, 2025

X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050
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TMPRSS11D特异性和自动切割激活的结构基础

Bryan J Fraser1,2, Ryan P Wilson3, Sára Ferková4,5

  • 1Structural Genomics Consortium Toronto, Toronto, ON, Canada. Bryanj.fraser@utoronto.ca.

Nature communications
|May 10, 2025
PubMed
概括

像TMPRSS2和TMPRSS11D这样的跨膜蛋白酶会激活自己进入病毒. 新的抑制剂显示出希望,但现有的药物如纳法莫斯塔特酸对TMPRSS11D有局限性.

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