绘制人类肠道细菌中农药诱导的代谢变化
Li Chen1,2, Hong Yan3,4, Shanshan Di5
1Human Nutrition Program, Department of Human Sciences, The Ohio State University, Columbus, OH, 43210, USA.
Nature communications
|May 10, 2025
概括
杀虫剂改变肠道细菌及其新陈代谢,影响宿主健康. 这项研究绘制了这些相互作用的地图,揭示了通过肠道微生物群诱导农药炎症的机制.
科学领域:
- 微生物学 微生物学
- 环境毒理学环境毒理学
- 代谢学 代谢学 代谢学
背景情况:
- 杀虫剂对肠道微生物群组成的影响尚未完全理解.
- 肠道微生物群在宿主健康和新陈代谢中起着至关重要的作用.
- 了解农药-微生物群相互作用对于评估环境健康风险至关重要.
研究的目的:
- 研究农药对肠道微生物生长和新陈代谢的影响.
- 构建农药-肠道微生物群-代谢物相互作用的全面网络.
- 阐明关联农药暴露,肠道微生物群和宿主炎症的分子机制.
主要方法:
- 用农药培养各种肠道微生物物种以评估生长.
- 使用代谢学分析细菌代谢物的变化.
- 开发一种农药-肠道微生物群-代谢物相互作用网络.
- 利用体内小鼠模型研究宿主微生物群相互作用和炎症.
主要成果:
- 农药被发现可以抑制或促进特定肠道微生物物种的生长.
- 数百种细菌代谢物因农药暴露而改变.
- 一个网络确定了306种农药-肠道微生物群对与相关的代谢变化.
- 在小鼠中,农药暴露导致了由改变的微生物脂质代谢介导的炎症.
结论:
- 杀虫剂显著改变肠道微生物群的组成和功能.
- 创建了一个关于农药-肠道微生物群-代谢物相互作用的详细地图.
- 微生物群调节的代谢失调是农药诱导宿主炎症的关键机制.
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