饮食性炎症及其对抑郁症老年人充血性心力衰竭的影响
Jiajing Zhao1, Yuhan Wang1, Chuxin Lv1
1Nanjing University of Chinese Medicine, 282 Hanzhong Road, Nanjing, 210029, Jiangsu, China.
Scientific reports
|May 10, 2025
概括
通过饮食炎症指数 (DII) 测量的促炎症饮食与患有抑郁症状的老年人患上充血性心力衰竭 (CHF) 的风险更高有关. 饮食改变可能有助于减轻这种心血管风险.
科学领域:
- 营养流行病学 营养流行病学
- 心血管疾病研究研究
- 老年医学 老年医学
背景情况:
- 抑郁症显著导致全球残疾,并影响生活质量.
- 新出现的证据将抑郁症与心血管疾病联系起来,例如充血性心力衰竭 (CHF),可能是由饮食引起的炎症介导的.
- 影响慢性炎症的饮食模式越来越多地被认为是各种健康状况的危险因素.
研究的目的:
- 调查饮食炎症指数 (DII) 与抑郁症状的老年人中充血性心力衰竭 (CHF) 的患病率之间的联系.
- 探索饮食炎症潜力的作用在患有抑郁症的人群中心血管不全的发展.
- 在抑郁人口中确定特定的年龄组,这些年龄组更容易受到与饮食相关的CHF风险的影响.
主要方法:
- 从国家健康和营养检查调查 (NHANES) 跨越2005-2018年的数据进行横截面分析.
- 根据抑郁症状和充血性心力衰竭 (CHF) 状态对参与者的分类.
- 从饮食摄入数据和使用通用线性模型 (GLM) 和趋势测试的统计评估来计算饮食炎症指数 (DII) 评分.
主要成果:
- 在患有抑郁症状的人群中,较高的DII分数和充血性心力衰竭 (CHF) 发生率增加之间观察到显著的正相关性 (OR: 1.122,95%CI: 1.041,1.209).
- 亚组分析显示,患有抑郁症状的老年人 (≥60岁) 对饮食炎症对心血管疾病风险的影响的脆弱性增加.
- 在患有抑郁症状的年轻参与者 (<60岁) 中,没有发现DII和CHF之间的显著关联.
结论:
- 较高的炎症性饮食坚持,由较高的DII得分表明,与抑郁症状的老年人患心脏不全 (CHF) 的风险增加有关.
- 旨在减少炎症的饮食干预措施可能是减轻这一脆弱人口群体中心血管疾病风险的关键策略.
- 这些发现强调了考虑饮食模式在抑郁症患者,特别是老年人心血管疾病的管理和预防中的重要性.
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