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隔离的四肢输液或输液作为第一线对第二线治疗中途转移性黑色素瘤

Michelle M Dugan¹, Aleena Boby², Helana Ghali²

¹Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL, USA.

Annals of surgical oncology

|May 10, 2025

概括

孤立的肢体输液和输液 (ILI/ILP) 有效地治疗黑色素瘤转移转移 (ITM). 虽然一线ILI/ILP显示了更高的响应率,但它没有改善生存率,证实了其作为二线治疗的价值.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
黑色素瘤研究黑色素瘤研究

背景情况:

过境转移 (ITM) 影响10%的高风险黑色素瘤患者.
孤立的肢体输液和 perfusion (ILI/ILP) 是已建立的ITM的治疗方法.
在治疗顺序中,ILI/ILP的最佳时间仍未确定.

研究的目的:

为了比较隔离四肢输液和 perfusion (ILI/ILP) 的疗效,当用于第一线或二线治疗不可切割的黑色素瘤转移转移 (ITM).

主要方法:

一项回顾性国际多机构研究分析了2006年至2023年期间364名无法切除的ITM患者的数据,这些患者接受了ILI/ILP治疗.
患者的分类是基于ILI/ILP是否作为一线 (n=329) 或二线 (n=35) 治疗.
评估了包括整体反应率 (ORR),现场无进展生存率 (PFS),现场外PFS和整体生存率 (OS) 在内的结果.

主要成果:

总体反应率 (ORR) 在一线ILI/ILP (84%) 与二线 (68%) (P=0.02) 相比显著更高.
完全响应 (CR) 和部分响应 (PR) 的比率为第一线的84%,而第二线的比例为67%.
在两组之间,没有观察到在实地PFS中位数 (10.8与8.1个月;P=0.2),在场外PFS (13.5与15.3个月;P=0.4) 或整体存活时间 (4.1与4.5年;P=0.7) 的统计学显著差异.

结论:

一线和二线ILI/ILP都显示出不可切除的黑色素瘤ITM的高整体响应率.
尽管在一线治疗中ORR较高,但在现场PFS缺乏差异表明,当IIL/ILP作为二线治疗时,它是一种有效的救援疗法.

关键词:

在运输中的黑色素瘤.在过境转移的转移.孤立的四肢输液.隔离的肢体输液.发生转移的黑色素瘤.区域化疗是一种区域化疗.治疗线路的治疗疗法.

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