在脊髓麻醉下选择性剖腹产前口服碳水化合物加载后,母亲和带血纯素度:一项随机对照试验
Katarzyna Kotfis1, Dominika Jamioł-Milc2, Arleta Wojciechowska3
1Department of Anesthesiology, Intensive Care and Pain Management, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland. katarzyna.kotfis@pum.edu.pl.
BMC pregnancy and childbirth
|May 10, 2025
概括
在剖腹产前进行手术前的口服碳水化合物加载,降低了母亲和带血中的纯素水平. 这种干预可以通过影响纯能路径和ATP代谢来优化孕产妇和新生儿的健康.
科学领域:
- 产科和妇科 产科和妇科
- 麻醉学 麻醉学
- 新生儿研究新生儿研究
背景情况:
- 在选择性剖腹产之前,标准的手术前禁食协议是常见的.
- 术前营养对母亲和新生儿的纯素代谢的影响尚未完全理解.
- 正在探索口服碳水化合物负载作为长时间禁食的替代方案.
研究的目的:
- 评估手术前口服碳水化合物摄入与标准禁食对孕产妇和带血纯素水平 (低氨酸,香氨酸,尿酸) 和β-甲酸 (β-HB) 的影响.
- 在选择性剖腹产的背景下,研究碳水化合物负载对纯素代谢标记物的影响.
主要方法:
- 一项前性随机临床试验,涉及148名接受选择性剖腹产的患者.
- 患者被随机分配,在手术前2小时接受口服碳水化合物饮料或标准禁食.
- 用高性能液态染色学测量了母体和带血液中的血纯素度.
主要成果:
- 碳水化合物负载在母体和带血中显著降低了低氨酸和氨酸度.
- 两组之间没有观察到β-hydroxybutyrate (β-HB) 水平的显著差异.
- 对所有主要结果指标 (p < 0.05) 实现了统计显著性.
结论:
- 手术前的口服碳水化合物负载与在经历剖腹产的母亲和新生儿的血纯素水平较低有关.
- 这一发现表明,纯能途径和ATP代谢在孕产妇与胎儿之间的关系中可能发挥作用.
- 碳水化合物负载可能代表一个有益的干预,以优化母亲和新生儿的健康.
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