在预测早期发作和晚期发作的胎儿生长限制方面,新的第一季度循环血管原生生物标志物:一个病例控制研究
Xiaoyi Bai1,2, Wei Li3, Wenjing Ding1
1Department of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.
BMC pregnancy and childbirth
|May 10, 2025
概括
早期检测胎儿生长限制 (FGR) 可以使用新的第一季度生物标志物来改进. 可溶性神经素-1 (sNRP-1),sPECAM-1和PDGF-AB/BB在预测早期发作的FGR方面表现有前途.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 生物标志物发现发现
背景情况:
- 胎儿生长限制 (FGR) 的第一季度预测目前是低于最佳的.
- 需要新的循环血管原生生物标志物来改善早期FGR检测.
研究的目的:
- 为了确定新的循环血管原生生物标志物,用于预测第一季度早期和晚期发作的FGR.
- 用接收器操作特征 (ROC) 曲线分析来评估这些生物标志物的预测性能.
主要方法:
- 一个病例控制研究涉及73个单独怀孕的FGR (早期或晚期发病) 和73匹配的正常对照.
- 怀孕11-13周的母体血清样本使用MILLIPLEX®磁珠面板对36种血管原生生物标志物进行了分析.
- 显示显著差异的生物标志物通过ROC曲线进一步分析.
主要成果:
- 在早期发病的FGR中,与对照人群相比,观察到可溶性神经素-1 (sNRP-1) 和可溶性血小板和内皮细胞粘附分子-1 (sPECAM-1) 的水平显著更高.
- 在早期发病的FGR中发现了较低水平的血小板衍生生长因子AB/BB (PDGF-AB/BB) 和PAPP-A.
- 这些生物标志物的组合实现了早期FGR预测的AUC为0.83,超过了单独的PAPP-A.
结论:
- 可溶性神经素-1 (sNRP-1),sPECAM-1和PDGF-AB/BB被确定为预测早期FGR的新一代第一季度生物标志物.
- 这些生物标志物有可能改善FGR的早期检测.
- 对于晚期发病的FGR的预测性能在测试的生物标志物中不那么显著.
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