阴茎癌:75岁以上和75岁以下患者之间的差异
Yoji Murakami1, Takahiro Yamaguchi2, Masato Goya3
1Department of Urology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Kumamoto, Japan.
概括
较年长的阴茎癌患者 (≥75岁) 的生存率较差,特别是在3期疾病中. 这可能是由于这个年龄组的健康状况较差,治疗不那么积极.
科学领域:
- 在瘤学瘤学.
- 老年医学 老年医学
- 手术瘤学手术瘤学
背景情况:
- 阴茎癌不成比例地影响着老年男性.
- 关于阴茎癌治疗和结果的年龄相关差异的数据有限.
研究的目的:
- 为了比较75岁及以上的阴茎癌患者与75岁以下患者的患者特征,治疗方法和癌症特异性存活率.
主要方法:
- 对2009年至2020年期间在12家医院接受治疗的196名阴茎癌患者的回顾性分析.
- 对75岁以上 (n=80) 和75岁以下 (n=116) 患者的结局进行比较.
主要成果:
- 老年患者 (≥75岁) 患有临床第3阶段阴茎癌,癌症特异性存活率明显降低.
- 年龄较大的组呈现出较差的东部合作性瘤组绩效状态,较低的白蛋白和较高的中性粒细胞与淋巴细胞比率.
- 在老年患者中观察到不太激进的治疗方法,包括阴茎部分切除和较少的骨盆淋巴结剖析.
结论:
- 高龄 (≥75岁) 与阴茎癌的癌症特异性生存率较差有关,特别是在3期疾病中.
- 老年患者的性能状况受损和治疗强度降低可能导致生存结果较差.
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