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Updated: May 14, 2025

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Published on: August 4, 2018

在肝移植期间使用粘性elastometry检测高纤维素分解.

Sarah Thaler¹, Anna Zorn¹, Isabell Aster¹

¹Department of Anaesthesiology, LMU University Hospital, LMU Munich, Munich, Germany.

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概括

此摘要是机器生成的。

基于ecarin的测试 (ECA测试) 比基于组织因子的测试 (EX测试) 更敏感,用于检测肝移植期间的过纤维素解,更频繁和更早地识别.

关键词:

这是一个ECA测试.凝血是凝固的过程.超纤维素溶解 (hyperfibrinolysis) 是一种超纤维素溶解.肝移植肝移植肝移植粘性弹性电磁测量 (VES) 是一种粘性弹性电磁测量.

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Last Updated: May 14, 2025

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

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科学领域:

凝血和血液静止作用
移植医学移植医学
临床诊断临床诊断临床诊断

背景情况:

末期肝病会破坏血静,称为重新平衡的血静.
肝移植进一步破坏了静血平衡.
过敏纤维素溶解是肝移植期间的一个严重并发症.

研究的目的:

为了评估肝移植期间高纤维素溶解的发生率.
为了比较基于ecarin的测试 (ECA测试) 与基于组织因子的测试 (EX测试) 在监测高纤维素分解中的有效性.

主要方法:

一项前性观察性研究,涉及30例肝移植.
使用ClotPro测定 (EX测试,FIB测试,AP测试,ECA测试) 在五个时间点进行粘弹性监测.
超纤维素溶解定义为最大溶解≥15%;溶解检测时间 (LDT) 测量了溶解速度.

主要成果:

与EX测试相比,ECA测试更频繁地 (21%对15%,p=0.039) 检测到高纤维素分解,并且在更多患者中检测到.
通过ECA测试显著提前检测到过敏纤维素分解 (LDT中位数为2100s与3300s,p<0.001).

结论:

基于ecarin的测试表明,在肝移植期间监测高纤维素分解的灵敏度更高.
与基于组织因子的测试相比,ECA测试可以更频繁,更早地检测过纤维素分解.