快速揭露安全香水的危害
Gertrud E Morlock1, Julia Heil2
1Institute of Nutritional Science, Chair of Food Science, and Interdisciplinary Research Center, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany; Center for Sustainable Food Systems, Justus Liebig University Giessen, Senckenbergstr. 3, 35390 Giessen, Germany.
Journal of chromatography. A
|May 11, 2025
概括
香水含有危害人类健康的危险化学物质,安全性评估通常是理论性的. 一种新的选方法揭示了香水中广泛存在的风险,敦促制定更安全的产品和监管.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 分析化学 分析化学
背景情况:
- 香水是复杂的化学混合物,对人类健康的影响尚不清楚.
- 目前对香水的风险评估往往是理论性的,专注于单个成分,而不是整个产品.
- 对于完整的香水配方,与危险相关的分析存在重大差距.
研究的目的:
- 开发和实施一个可持续的,非目标化学品安全选整个香水.
- 识别与商业香水相关的潜在危险和不良影响.
- 为作为消费产品的香水提供全面的危险概况.
主要方法:
- 开发了一种新的可持续的非目标化学品安全选方法.
- 42种随机收集的香水在没有先前样本准备的情况下进行了选.
- 查评估了十种不良影响:基因毒性,细胞毒性,抗菌活性 (格拉姆阴性和阳性),神经毒性/调节,内分泌干扰 (芳酶抑制,抗/雌激素,抗/雌激素活性).
主要成果:
- 在所有测试的香水中检测到许多危险化合物,无论价格或预期的性别用途.
- 观察到显著的基因毒性 (EC50 = 1.3 μL) 和芳香酶抑制 (IC50 = 11 nL).
- 一个100μL的香水喷雾剂显著超过了基因毒性 (77倍) 和芳酶抑制 (9,090倍) 的安全值.
结论:
- 这项研究提供了首次对整个香水进行了深入的与危害相关的分析,揭示了它们是危险化学物质进入人体的潜在入口途径.
- 这些发现使利益相关者能够开发无危害的香水,鼓励当局主动进行安全选,并支持向可持续分析方法过渡.
- 该研究强调,香水行业迫切需要改进监管和伦理考虑,以保护消费者健康.
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