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Updated: May 13, 2025

On-chip Isotachophoresis for Separation of Ions and Purification of Nucleic Acids
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通过使用代数学和人工中性网络建模方法的离子交换色谱来分离Fab治疗电荷变体

Anupa Anupa1, Pratik Punj2, Lalita Kanwar Shekhawat2

  • 1School of Interdisciplinary Research, Indian Institute of Technology Delhi, New Delhi, India.

Journal of chromatography. A
|May 11, 2025
PubMed
概括

开发一个强大的染色体净化工艺对于Fab抗体疗法至关重要. 这项研究引入了一种新的方法,使用数学和人工智能建模将线性梯度转换为阶梯度,简化生物制造.

关键词:
抗原结合片段 (Fab) 抗体的抗体.离子交换色谱 (IEX) 是一种离子交换色谱.线性梯度化 (LGE),山本法方法.数学的建模数学建模基于物理的中立网络模型 (PINN)

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