营养素检测途径用于食品增强和和
Aaron D McKnight1, Amber L Alhadeff1
1Monell Chemical Senses Center, Philadelphia, 19104, PA, United States; Department of Neuroscience, University of Pennsylvania, Philadelphia, 19104, PA, United States.
Current opinion in neurobiology
|May 11, 2025
概括
肠-大脑信号通路检测营养物质以控制食行为,影响食物摄入和终止. 需要进一步的研究来澄清食物强化和和的不同机制.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 身体生理学 身体生理学
背景情况:
- 摄入的食物被分解成宏观营养素,触发肠-大脑信号通路,这对于调节养行为至关重要.
- 这些通路介导着食物摄入的启动 (食欲,强化) 和停止 (和).
- 虽然已经取得了进展,但食物增强和和的独特机制需要进一步阐明.
研究的目的:
- 审查营养感应受体/输送器和与养行为有关的肠-大脑通路.
- 为了确定关键的知识差距,了解肠-大脑信号在食品摄入调节.
- 为了指导未来研究肠-大脑系统和养行为之间的复杂相互作用.
主要方法:
- 关于肠-大脑信号传递,营养感应和养行为的科学出版物的文献综述.
- 分析当前对食欲,强化和和途径的理解.
- 识别知识缺口和未来研究领域.
主要成果:
- 肠-大脑信号通路对于检测宏观营养素和调节养行为至关重要.
- 胃口/强化和腹路径都对控制食物摄入至关重要.
- 关于区分食物增强和和的精确机制,仍然存在重大知识差距.
结论:
- 了解营养感应中的肠-大脑信号对于理解养行为至关重要.
- 需要进行进一步的研究,以界定食物强化和和背后的特定分子和神经机制.
- 解决这些知识差距将推动我们对食欲调节的理解,并可能为饮食障碍提供干预信息.
相关概念视频
Regulation of Food Intake
205
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
205
Key Elements for Plant Nutrition
18.7K
Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the...
18.7K
Neural Regulation
39.2K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.2K
Primary Motives: Hunger and Thirst
170
Hunger and thirst are fundamental physiological drives crucial for maintaining homeostasis and ensuring the survival of both humans and animals. These drives are regulated through complex interactions between the brain, hormones, and sensory receptors.
Hunger arises when the brain detects changes in the body's nutrient levels, including glucose, lipids, amino acids, and hormones such as ghrelin and leptin. The hypothalamus plays a central role in hunger regulation. The lateral hypothalamus...
Hunger arises when the brain detects changes in the body's nutrient levels, including glucose, lipids, amino acids, and hormones such as ghrelin and leptin. The hypothalamus plays a central role in hunger regulation. The lateral hypothalamus...
170
The Physiology of Taste
3.8K
The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the...
3.8K
Gustation
47.7K
Gustation is a chemical sense that, along with olfaction (smell), contributes to our perception of taste. It starts with the activation of receptors by chemical compounds (tastants) dissolved in the saliva. The saliva and filiform papillae on the tongue distribute the tastants and increase their exposure to the taste receptors.
47.7K


