在SARS-CoV-2感染后24个月的症状负担和后COVID-19综合征:长度基于人口的研究研究
Raphael S Peter1, Lisamaria Sedelmaier1, Alexandra Nieters2
1Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
The Journal of infection
|May 11, 2025
概括
在SARS-CoV-2感染后两年,高症状患病率持续存在,尽管许多症状消失. 在很大一部分人身上出现了新的症状,影响了他们的生活质量.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 感染SARS-CoV-2的长期健康后果,通常称为后COVID-19综合征 (PCS),仍然是一个重大的公共卫生问题.
- 了解PCS症状的持续和演变对于患者管理和医疗保健规划至关重要.
研究的目的:
- 在最初的SARS-CoV-2感染两年后,评估症状负担和功能障碍.
- 调查COVID-19后症状的解决和出现,并确定相关因素.
主要方法:
- 德国西南部最初于2021年进行的一项基于人口的调查于2023年进行了后续调查.
- 6635名参与者被重新评估,以确定PCS的流行率和两个时间点的特定症状集群 (感染后平均8.7个月和23.9个月).
- 进行了统计分析,以确定症状消失或出现的预测因素及其对健康相关生活质量 (hrQoL) 的影响.
主要成果:
- PCS的点患病率在感染后大约9至24个月之间保持稳定 (29.9%对31.2%).
- 关键症状集群的患病率,如疲劳,神经认知障碍和胸部症状显示最小的变化.
- 症状的缓解和出现率相似;女性性别,肥胖和急性感染治疗预测出现症状.
结论:
- 在SARS-CoV-2感染两年后,很大一部分人会经历持续的症状.
- 虽然9个月后出现的症状往往会消失,但有相当数量的新症状出现,独立于再感染.
- 确定的症状集群显著影响了与身体和心理健康有关的生活质量.
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