在绝经后的妇女中,循环炎症标志物与失调的食后代谢有关
Carlos M Donado-Pestana1, Amanda D Vasconcelos2, Vinicius B Mantovam2
1Department of Food and Experimental Nutrition. School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil; Food Research Center FoRC, University of São Paulo, São Paulo, SP, Brazil.
与生育年龄妇女相比,绝经后妇女表现出一种亲炎症状态和代谢功能障碍. 这包括腹部脂肪增加,血糖和脂质升高,基因表达改变,表明慢性疾病风险.
科学领域:
- 代谢研究的研究.
- 妇女健康 妇女健康
- 内分泌学 在内分泌学.
背景情况:
- 更年期会导致生理变化,增加慢性疾病的风险.
- 评估食后反应揭示了代谢健康和疾病倾向.
- 腹内脂肪组织和代谢标记是关键指标.
研究的目的:
- 为了研究和比较绝经后 (PM) 和生殖年龄 (RA) 妇女的食后代谢.
- 为了确定两个群体之间的代谢和炎症差异.
- 评估与绝经后妇女慢性疾病风险相关的生物标志物.
主要方法:
- 横截面研究设计. 截面研究设计.
- 饮食挑战,混合饮食,然后进行6小时的血液采样.
- 测量血糖,脂质,乳酸,白细胞和血细胞因子.
- 对外围血液单核细胞 (PBMC) 基因表达的分析.
主要成果:
- 绝经后的女性比生育年龄的女性有显著更多的腹内脂肪组织.
- 在PM女性中观察到禁食和食后血糖和脂血的升高.
- 孕妇的PM表现出一种促炎特征,增加了MCP-1和TNF-α,并改变了PBMC基因表达.
- 两组之间观察到明显的食后隐形素动力学.
结论:
- 绝经后的女性表现出一种促炎状态和代谢恶化.
- 这些代谢和炎症变化表明慢性疾病的风险增加.
- 这些发现强调了在绝经后妇女中代谢评估的重要性.
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