身体组成和肺功能在预测肺癌手术后的长期生存中的作用
Koen C H A Verkoulen1, Aimée J P M Franssen1, Yvonne L J Vissers1
1Department of Surgery, Division of General Thoracic Surgery, Zuyderland Medical Center, Heerlen, the Netherlands.
Clinical nutrition ESPEN
|May 11, 2025
概括
减少的肺功能 (FEV1%) 和低的骨肌指数 (SM指数) 与肺癌手术患者的生存率下降有关. 高水平的皮下脂肪组织辐射衰减 (SAT-RA) 也会影响生存率,特别是在肺功能良好的人群中.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 肺部病理学 肺部病理学
背景情况:
- 肺癌的TNM分期系统忽略了宿主因素,如身体组成和肺功能.
- 评估这些因素可以改进肺癌患者的治疗决策和预后.
研究的目的:
- 研究肺癌手术患者的身体组成,肺功能和整体存活率之间的关联.
- 确定宿主表型是否可以为肺癌治疗和预后提供信息.
主要方法:
- 计算机断层扫描 (CT) 扫描分析了骨肌肉组织 (SM),内脏脂肪组织 (VAT) 和皮下脂肪组织 (SAT) 指数和辐射减弱 (RA).
- 肺功能通过1秒内强制呼气体积 (FEV1%) 进行评估.
- 用于评估生存关联的多变量考克斯回归和卡普兰-梅尔分析.
主要成果:
- 低FEV1%,低SM指数和高SAT-RA显著与总生存率下降有关.
- 高SAT-RA特别影响高FEV1%的患者的生存率.
- FEV1%和SM指数 (SMRA) 与肺功能有关.
结论:
- 身体组成 (SM指数,SAT-RA) 和肺功能 (FEV1%) 是肺癌手术患者生存的关键预测因素.
- 将宿主表型纳入临床决策可能会改善肺癌管理.
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