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Updated: May 20, 2025

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography

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在健康的生物基质中选择元素和金属的参考范围.

Mohammad Hassan Emami¹, Safoora Mohammadzadeh¹, Nasrin Zare²

¹Poursina Hakim Digestive Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Pooya Zist-Mabna Hakim Company, Poursina Hakim Institute, Isfahan, Iran.

Clinica chimica acta; international journal of clinical chemistry

|May 11, 2025

概括

本次审查强调了对生物样本中元素和金属的局部参考值的需求. 标准化方法对于准确的临床评估和全球多样化人口的生物监测至关重要.

关键词:

生物样本是指生物样本.血液血液血液血液一个元素一个元素一个元素头发头发头发头发头发金属金属金属金属参考值是指参考值的使用情况.

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Last Updated: May 20, 2025

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography

Published on: January 17, 2020

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科学领域:

环境健康环境健康
分析化学分析化学
临床生物化学临床生物化学

背景情况:

确定生物样本中元素和金属的可靠参考值 (RV) 对准确的健康评估至关重要.
由于地理,人口和分析差异,现有的RVs有很大的差异.
需要对当前的RV进行全面的全球审查,以确定差异并指导未来的研究.

研究的目的:

整合和比较全球健康人口生物样本中元素和金属的现有参考值.
为了识别不同国家和方法的报告参考值的变化.
强调需要本地化和标准化的参考值.

主要方法:

使用Web of Science,PubMed和Scopus进行了系统的文献审查.
包括的研究是在2012年1月至2022年2月期间以英语出版的.
符合条件的研究涉及至少120名参与者,评估了至少3种元素/金属,并分析了生物样本 (全血,血清,血,带,头发).

主要成果:

包括来自15个国家的29项研究,包括26676名年龄在0-80岁之间的健康个体.
提取了36种痕迹/微/美索/宏/有毒金属和元素的数据.
观察到参考范围,平均值,中位数和置信区间的显著变化,这些变化归因于地理因素,人口统计和分析方法.

结论:

局部化参考值对于准确的临床评估和生物监测至关重要.
需要标准化分析方法来确保结果的可比性和可靠性.
需要对不同种群进行进一步的广泛研究,以制定元素和金属的综合参考值.