在视网膜静脉封闭中发生系统性不良事件的风险
Emily A Albrecht1, Priya Shukla2, Alison H Zhao3
1Case Western Reserve University School of Medicine, Cleveland, Ohio.
Ophthalmology. Retina
|May 11, 2025
概括
中心和分支视网膜静脉封闭显著增加死亡,心肌梗塞,中风和心血管疾病的风险. 对CRVO的高强度治疗可能会增加心脏病发作风险,这强调了系统评估的必要性.
科学领域:
- 眼科医生 眼科 眼科
- 心血管医学 心血管医学
- 神经学 神经学
背景情况:
- 关于中央和分支视网膜静脉封闭 (CRVO和BRVO) 与全身不良事件之间的关联,存在相互矛盾的数据.
- 本研究使用美国大型医疗保健数据库调查了这一联系.
研究的目的:
- 检查CRVO和BRVO与系统性不良事件之间的关联.
- 为了比较高强度 (≥10注射) 和低强度 (≤5注射) 抗VEGF治疗之间的风险.
主要方法:
- 基于人口的回顾性队列研究,使用从2006年到2024年的非识别数据.
- 国际疾病分类,第10次修订代码用于识别CRVO和BRVO队列.
- 倾向性得分匹配适用于人口统计,药物和并发症. 计算了风险比率 (RRs).
主要成果:
- 无论是CRVO还是BRVO,都与死亡,心肌梗塞 (MI),出血性中风,缺血性中风和心血管疾病的风险显著增加有关.
- 与低强度治疗相比,对CRVO的高强度治疗显示了心脏病发作风险的增加.
- 在BRVO中,高强度治疗与低强度治疗之间没有发现系统性事件风险的显著差异.
结论:
- CRVO和BRVO与更高的系统性重大不良事件风险有关,包括心血管和脑血管疾病.
- 针对CRVO的高强度抗VEGF治疗可能与心脏病发作风险增加有关.
- 对被诊断患有视网膜静脉封闭症的患者来说,系统性评估至关重要.
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