一个随机对照试验的propranolol在长期劳动的无产期患者
Yaneve N Fonge1, Helen B Gomez Slagle2, Richard J Caplan3
1Minnesota Perinatal Physicians, Allina Health System, Minneapolis, MN.
American journal of obstetrics & gynecology MFM
|May 11, 2025
概括
普罗普拉诺洛尔并没有缩短长期诱导分娩的无产期个体的分娩时间. 这项研究没有发现分娩时间或阴道分娩率的显著益处,质疑其在这种情况下的使用.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 在怀孕期间的药理学
背景情况:
- 长期诱导分娩 (IOL) 在无胎儿的个体可以延长分娩时间.
- 普罗普拉诺洛尔 (propranolol) 已被研究为其在诱导后缩短分娩的潜力.
研究的目的:
- 为了评估propranolol在减少分娩时间的有效性,在诱导后经历长时间潜伏分娩的无孕个体中.
- 为了确定布拉诺洛尔的使用是否会影响分娩时间,阴道分娩率或剖腹产率.
主要方法:
- 一个开放的随机临床试验,涉及80名无产妇参与者,在预产期接受IOL治疗.
- 参与者接受了静脉注射普拉诺洛尔或长期潜伏分娩的常规护理 (定义为没有宫变化≥8小时与破裂的膜和催产素).
- 主要结果是分娩的时间;次要结果包括阴道和剖腹产的分娩率,以及活跃分娩的时间.
主要成果:
- 与常规护理相比,用普罗普拉诺洛尔的管理并没有显著减少到分娩的中位数时间 (27.7小时与30.4小时).
- 在24小时内通过阴道分娩和剖腹产的发育率在罗和通常护理组之间是相似的.
- 在时间到活跃分娩或孕产妇/新生儿结局方面没有观察到显著差异.
结论:
- 普罗普拉诺洛尔的使用似乎不会缩短分娩时间或增加阴道分娩率,在诱导后长期潜伏分娩的无卵性个体中.
- 目前的研究结果不支持使用propranolol来管理这种患者群体中长期潜伏分娩的情况.
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