丽钟可以通过调节肠道微生物群-SCFA-Th17/Treg轴来缓解实验性性结肠炎
Hengjun Huang1, Chengyu Yang1, Silu Li1
1Jiangxi Province Key Laboratory of Traditional Chinese Medicine Pharmacology, Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang, 330115, China; Jiangxi Health Industry Institute of Traditional Chinese Medicine, Nanchang, 330115, China.
Journal of ethnopharmacology
|May 11, 2025
概括
(Lizhong) (LZD) 通过平衡肠道微生物群和T细胞免疫力来预防性结肠炎. 这种传统药物增强了短链脂肪酸 (SCFA) 的产生,这对其治疗效果至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 丽钟 (LZD) 是一种传统中医药配方,用于胃肠道疾病.
- 性结肠炎 (UC) 是结肠的慢性炎症状况.
研究的目的:
- 研究肠道微生物群和T细胞平衡在LZD对UC的保护作用中的作用.
- 阐明LZD在治疗UC的有效性背后的机制.
主要方法:
- 用德克斯硫酸 (DSS) 诱导的大肠炎小鼠模型来评估LZD的预防作用.
- 用16S rDNA测序分析了肠道微生物组成.
- 量化了T细胞种群 (Th17/Treg比率) 和短链脂肪酸 (SCFA).
主要成果:
- 在DSS诱导的大肠炎小鼠中,LZD显著缓解了体重减轻和结肠损伤.
- 治疗LZD促进了Th17/Treg细胞平衡,并增加了SCFA水平.
- LZD的保护作用取决于肠道微生物群,SCFA生产细菌的丰富性增加.
结论:
- 通过调节肠道微生物群和促进Th17/Treg细胞平衡,LZD可以改善性结肠炎.
- 该机制涉及肠道微生物群-SCFA通路,突出显示了LZD对UC的治疗潜力.
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