兴奋剂药物的使用和精神病体验的风险
Kirstie O'Hare1,2, Jonah F Byrne1,3,4, Hugh Ramsay1,5
1Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Pediatrics
|May 11, 2025
概括
对青少年注意力缺陷/多动症的兴奋剂处方不会因果地增加精神病的经历. 观察到的关联很可能是由于影响治疗和经验的混因素.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 儿科 儿科 儿科
背景情况:
- 在年轻人中,针对注意力缺陷/多动障碍 (ADHD) 的兴奋剂药物的处方正在增加.
- 人们对兴奋剂的潜在精神病原性影响存在担忧.
- 以前的研究表明,青少年处方兴奋剂增加了精神病经历的风险.
研究的目的:
- 估计兴奋剂处方对年轻人精神病体验的因果关系.
- 研究ADHD药物治疗与精神病风险之间的关系.
主要方法:
- 使用青少年大脑认知发展研究数据的试验模拟 (N=8391).
- 年龄在9-14岁之间的参与者.
- 双重可靠的估计 (治疗权重和标准化的反向概率) 来评估因果关系.
主要成果:
- 在未加权分析中,兴奋剂处方与精神病体验有关 (OR: 1.46).
- 精神病体验也预测了兴奋剂治疗 (OR: 1.93).
- 两倍强大的估计发现没有证据表明兴奋剂处方对精神病体验的因果关系 (OR:1.09).
结论:
- 结果不支持兴奋剂处方和精神病体验之间的因果关系.
- 观察到的关联很可能被影响治疗决策和精神病风险的因素所混.
更多相关视频
05:52Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
14.6K
07:31Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
Published on: May 15, 2020
6.9K
相关概念视频
Psychosis and Antipsychotic Drugs: Overview
155
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
155
Antipsychotic Drugs: Therapeutic Uses and Side Effects
105
Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
105
Mania and Antimanic Drugs: Overview
103
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
103
Drug Therapy
30
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
30
CNS Stimulants: Psychedelic Agents
103
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
103
Psychosis: Goals of Pharmacotherapy
95
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
95
