多个循环生物标志物的预后价值对于心室失常症在左心室超 - - 纵向队列研究
概括
在患有左心室超 (LVHT) 的患者中,较高的内衣林-1水平预测心室节律失常 (VA). 升高的大内甲素-1和特定的超结位增加VA风险,有助于患者风险分层.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 遗传学 遗传学 是一个
背景情况:
- 室内节律失常 (VA) 是一个重要的风险因素对不良后果在患者的左室内缩 (LVHT).
- 确定LVHT中VA的预测生物标志物对于风险分层和管理至关重要.
研究的目的:
- 调查各种生物标志物的预测价值,用于诊断为左心室超结的患者出现心室失律.
- 在LVHT队列中探索大内甲蛋白-1度与VA风险之间的关联.
主要方法:
- 对265名LVHT患者进行了回顾性队列研究.
- 基线生物标志物的分析,包括N-终端亲B型尿素,大内甲蛋白-1,hs-CRP,尿酸和自由脂肪酸.
- 多变量考克斯回归和受限立方线分析来评估VA预测.
主要成果:
- 82名 (30.9%) 患者在4.34年的中位数随访期间经历了VA.
- 较高的大内甲素-1度独立地与增加的血管风险相关 (HR 1.513,P=0.005).
- 较高的大内甲蛋白-1水平,特别是>0.63 pmol/L,特别是在心肌病或特定的LV尺寸/功能时,表明对VA进行更密切的监测.
结论:
- 大度的内甲素-1作为一个独立的预测器的VA在LVHT患者.
- 超结的位置,与高的内甲素-1水平相结合,在这个人群中增加了VA的风险分层.
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