脂质积累产品与美国骨矿物质密度之间的关联 成年人,一个全国代表性的横截面研究
Aiyong Cui1, Yan Zhuang1, Xing Wei1
1Department of Orthopaedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, 710000, China.
Scientific reports
|May 11, 2025
概括
高水平的脂质积累产品 (LAP) 与美国成年人较低的骨矿物质密度 (BMD) 有关. 这表明LAP可以预测骨质疏松症风险.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 肥胖问题研究研究
背景情况:
- 脂质积累产物 (LAP) 是一种新兴的脂质过度积累和中心肥胖症的生物标志物.
- LAP与骨矿物质密度 (BMD) 之间的关联需要进一步调查.
研究的目的:
- 在美国成年人群中调查LAP和腰部BMD之间的关系.
- 探索潜在的非线性相关性和值效应.
主要方法:
- 使用多变量线性回归分析.
- 使用了受限制立方线 (RCS) 和值效应分析.
- 对3883名美国成年人进行了子组和相互作用测试.
主要成果:
- 在对共变量进行调整后,在ln-LAP和腰部BMD之间发现了显著的负非线性关联 (β=-0.011).
- 值效应分析显示,只有在2.846.6的拐点以上才有显著的负相关性.
- 在各个子组中没有观察到显著的相互作用效应.
结论:
- 升高的LAP与美国成年人腰部 BMD 的降低有关.
- LAP可以作为预测骨质疏松风险的有价值的临床指标.
- 这些发现支持针对骨质疏松症风险人口的早期干预策略.
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