[湿颗粒和连续制造技术的整合和创新:在线检测,建模和工艺扩展的审查]
Guang-di Yang1, Ge Ao2, Yang Chen3
1Guangxi University of Chinese Medicine Nanning 530200, China National Engineering Research Center of Chinese Medicine Solid Preparation Manufacturing Technology Nanchang 330006, China.
概括
连续制造提供了制药生产效率,但由于复杂性和成本,在湿颗粒中面临挑战. 本综述探讨了用于推进连续湿颗粒加工过程的关键技术.
科学领域:
- 制药制造业 制药制造业 制药制造业
- 化学工程是化学工程的重要组成部分.
背景情况:
- 连续制造 (CM) 与传统批量生产相比具有优势,包括提高效率和控制.
- 制药生产趋势有利于智能和高效的操作,但在湿颗粒中CM的采用仍然很缓慢.
- 高度的技术复杂性,大量的投资和严格的控制阻碍了CM在湿颗粒中实施.
研究的目的:
- 在连续制造中审查湿颗粒的当前应用.
- 确定和讨论用于连续湿颗粒的关键支持技术.
- 为制药湿颗粒制剂的创新和应用提供参考.
主要方法:
- 系统审查关于连续湿颗粒的当前文献.
- 专注于在线检测技术的进步,以实时监控.
- 分析过程建模和扩大规模的战略,以持续湿颗粒化.
主要成果:
- 连续制造在制药生产效率和控制方面提供了显著的优势.
- 连续湿颗粒处理的挑战包括技术复杂性,成本和缺乏标准化.
- 关键技术如在线检测,流程建模和扩展对于CM集成至关重要.
结论:
- 推进制药湿颗粒制造的连续制造需要解决技术和经济障碍.
- 在线检测,流程建模和扩展技术的开发对于成功的集成至关重要.
- 本综述提供了洞察力,以促进工艺创新和采用连续湿颗粒的采用.
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