[来自Berberis polyantha根的烯胺]
Dong-Mei Sha1, Shuai-Cong Ni1, Li-Niu Sha-Ma1
1Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China Chengdu 610225, China Sichuan Provincial Qiang-Yi Medicinal Resources Protection and Utilization Technology Engineering Laboratory Chengdu 610225, China.
概括
从Berberis polyantha根中分离出来的四种烯酸具有抗炎性质. 这些化合物有效地抑制了巨细胞中氧化的释放,表明了治疗潜力.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 药用化学 医学化学
背景情况:
- 柏柏里斯多塔 (Berberis polyantha) 是一种具有潜在药用功能的植物物种.
- 炎症是一种复杂的生物反应,与各种疾病有关.
- 氧化 (NO) 是炎症过程中的关键媒介.
研究的目的:
- 从Berberis polyantha根中分离和识别化学成分.
- 为了评估分离的化合物的抗炎活性.
主要方法:
- 使用多种色谱技术 (凝,HP20,聚胺,C18,HPLC) 系统地分离化合物.
- 使用光谱方法 (1D NMR,2D NMR,UV,MS,CD) 和物理化学性质的结构阐明.
- 在体外抗炎测定使用脂聚糖 (LPS) 诱导的RAW264.7巨细胞测量氧化 (NO) 释放.
主要成果:
- 他们分离了四种烯基胺: (2R) - 1 - 4 - - 4 - - 3 - 5 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 的新化合物,其中包括甲基氨基胺和甲基胺.
- 化合物2,3和4首次从B. polyantha中分离出来.
- 所有四种分离的化合物都在10μmol·L−1.1.7度下显著抑制了RAW264.7巨细胞中LPS诱导的NO释放.
结论:
- 贝贝里斯多塔的根含有具有抗炎功能的生物活性烯胺.
- 隔离的化合物,特别是新化合物1,需要进一步研究它们在炎症条件下的治疗应用.
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