低剂量ASA疗法在热干或热湿热应激期间不会改变核心或皮肤温度 (PSU HEAT项目)
Kat G Fisher1,2, Olivia K Leach2, Rachel M Cottle1,2
1Center for Healthy Aging, Pennsylvania State University, University Park, Pennsylvania, USA.
Physiological reports
|May 12, 2025
概括
低剂量阿司匹林 (ASA) 治疗在老年人热应激期间减少皮肤血液流动,但不会影响核心体温. 这一发现对于了解ASA的老龄化人口的温度调节至关重要.
科学领域:
- 身体生理学 身体生理学
- 环境健康 环境健康
- 老年学是指老年学的学科.
背景情况:
- 阿司匹林 (ASA) 被广泛用于50岁以上成年人的心血管预防.
- 低剂量的ASA抑制了循环氧化酶,影响了中年成年人的温度调节.
- ASA对老年人 (>65岁) 耐热度的影响尚不清楚.
研究的目的:
- 确定低剂量ASA对老年人热应激反应的温度调节和心血管反应的影响.
- 在热潮湿和热干环境中研究这些效应.
主要方法:
- 11名老年人 (66-80岁) 参加了这项研究.
- 参与者在服用低剂量ASA (81 mg/天) 或安慰剂7天后暴露于热应激.
- 测量包括核心和皮肤温度,心率,平均动脉压和前臂血流.
主要成果:
- 低剂量ASA在两个环境中显著减弱了前臂血流和前臂血管导电性 (p ≤0.04).
- 没有观察到ASA对核心或皮肤温度有显著影响.
- 这些发现在温暖潮湿和热干条件下是一致的.
结论:
- 低剂量阿司匹林治疗会损害老年人对热应激的皮肤血管反应.
- 尽管皮肤的血液流量发生了变化,但在温和的热量暴露期间,ASA不会影响核心体温的调节.
- 这表明,在老年人中,在ASA影响下,外周血管扩张和核心温度控制之间存在分离.
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