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慢性压力和大西洋鱼中类似抑郁症的神经内分泌特征的发展
Marco A Vindas1, Ole Folkedal2, Johan Aerts3,4
1Department of Paraclinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Norway.
The Journal of experimental biology
|May 12, 2025
概括
水产养殖鱼中二氧化碳升高的慢性压力导致类似抑郁的状态 (DLS). 这些鱼表现出应激反应受损和基因调节的改变,表明全静态过载.
科学领域:
- 水产养殖是水产养殖的一种方式.
- 鱼类生理学 鱼类生理学
- 压力生理学 压力生理学
背景情况:
- 水产养殖鱼可以发展出类似抑郁的状态 (DLS),表现为异常行为和皮质醇和血清激素的升高.
- 在鱼中DLS的原因尚未完全理解,但怀疑是慢性压力.
- 受影响的鱼类无法对额外的压力因素做出反应,这表明生理状态受到损害.
研究的目的:
- 研究由环境二氧化碳升高引起的慢性压力对大西洋鱼的影响.
- 为了确定慢性二氧化碳暴露是否会导致类似抑郁的状态和应激反应受损.
- 分析与鱼慢性压力相关的生理和转录性变化.
主要方法:
- 大西洋鱼在68天内暴露于环境中逐渐增加的二氧化碳度.
- 测量了血皮质类固醇 (皮质醇,皮质素) 和大脑血清激素 (5-HT) 的水平.
- 在基底和急性压力条件下分析了远脑基因表达.
主要成果:
- 暴露于二氧化碳的鱼类表现出高血皮质醇,皮质醇+皮质,以及大脑干中血清激素的长期信号.
- 与对照组不同的是,二氧化碳处理的鱼类未能增加大脑干的5-HT信号,以应对急性压力.
- 经过二氧化碳处理的鱼类对急性压力的转录反应与对照鱼类的转录反应相反.
结论:
- 长期暴露于高水平的二氧化碳会引起大西洋鱼的全静态过载状态,其特点是无法应对压力.
- 这种由压力引起的状态与鱼的抑郁状状态 (DLS) 现型有关.
- 慢性压力可能是水产养殖鱼中DLS发展的一个重要因素.
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