相关实验视频

Updated: Jul 6, 2026

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

作为控制,严重程度和慢性鼻炎复发的预测指标,组织中乙酸氨基基基水平

Julissa Vizcarra-Melgar¹, Serafín Sánchez-Gómez^2,3, Nuria López-González³

¹Department of Otorhinolaryngology and Head and Neck Surgery, Consorci Sanitari Integral, Sant Joan Despí Moisés Broggi Hospital, Barcelona, Spain.

Frontiers in allergy

|May 12, 2025

概括

组织中乙氨基细胞的计数不能预测具有鼻息肉 (CRSwNP) 结果的慢性鼻炎的结果. 然而,血中乙氨基酸水平与CRSwNP的严重程度和控制有关,这表明它们作为生物标志物的有用性.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

带有鼻息肉的慢性鼻炎 (CRSwNP) 经常与2型炎症有关,通过组织异osinophil数量来表明.
血液和粘膜层的乙氨基酸被提议作为CRSwNP严重性和控制的生物标志物.
在特定人群中,高组织乙氨基酸细胞计数可能与复发风险相关.

研究的目的:

调查组织乙氨基酸细胞数量与CRSwNP的控制,严重程度和复发之间的关联.
为了比较组织中乙酸细胞的数量与临床参数和血液中乙酸细胞的数量.

主要方法:

一项观察性研究包括108名患有CRSwNP的患者,他们接受了鼻腔粘膜活检.
收集的数据包括组织病理学,喘控制,CRSwNP控制和严重程度 (POLINA共识),生活质量 (SNOT-22),复发率和实验室标记.
组织中乙氨基酸细胞的数量与这些临床和实验室参数进行了比较.

主要成果:

81%的患者有组织乙酸细胞数>10/HPF,60.2%的患者有血液乙酸细胞.
血液中乙酸氨与CRSwNP的严重程度和控制有显著的相关性.
没有发现有意义的关联在组织乙氨基酸细胞数量和CRSwNP严重程度,控制或复发之间.

结论:

发现组织中乙氨基酸细胞计数不是可靠的标志物,用于预测该队列中CRSwNP的控制,严重程度或复发.
血中乙氨基酸水平与CRSwNP控制和严重程度有显著的关联,这表明它们作为临床生物标志物的价值.

关键词:

慢性鼻炎与鼻多生物标志物生物标志物疾病控制疾病控制埃索诺菲尔性炎症是什么意思复发性复发性复发性组织埃索诺菲利亚 (eosinophilia)这是一种2型炎症.

更多相关视频

Methodology for Sputum Induction and Laboratory Processing

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

相关概念视频

Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...