孕产妇运动对晚年小鼠后代神经发育和肠道微生物群的影响
Sang-Seo Park1, Tae-Woon Kim2, Bo-Kyun Kim3
1Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea.
Journal of exercise rehabilitation
|May 12, 2025
概括
老年母亲的孕产妇运动改善了后代的大脑发育,促进了神经发生和突触蛋白. 然而,它减少了后代的肠道微生物多样性.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 微生物组研究 微生物组研究
背景情况:
- 晚年母亲的年龄与子女神经发育受损有关.
- 母亲因素显著影响后代的大脑结构和功能.
- 母亲年龄,运动和后代肠道微生物组之间的相互作用尚未完全理解.
研究的目的:
- 研究母体运动对海马神经发生,突触蛋白表达和老雌性小鼠后代肠道微生物群的影响.
- 为了确定母亲的运动是否可以减轻后代与年龄有关的神经发育缺陷.
- 探索母亲运动对后代肠道微生物组成的影响.
主要方法:
- 利用小鼠模型与四组:年轻的后代 (CON),运动的年轻人,老年人 (AMA) 和运动的老年人 (AMA+EX) 的母亲.
- 使用5 - - 2'-脱氧氨/神经元双重免疫光染色评估海马神经发生.
- 通过使用16S rRNA测序的西部斑块和肠道微生物组组成分析了突触可塑性蛋白 (BDNF,PSD-95).
主要成果:
- AMA母亲的后代表现出降低的海马神经发生和较低的突触蛋白 (BDNF,PSD-95) 水平.
- 在AMA+EX组的孕产妇跑步机运动显著恢复了神经发生和突触蛋白表达.
- 母亲运动导致后代肠道微生物群的微生物丰富性和α多样性减少,特别是在AMA+EX组.
结论:
- 晚年母亲的年龄会对后代的海马神经发生和突触蛋白表达产生负面影响.
- 母亲的运动可以改善后代与年龄有关的神经发育障碍.
- 孕产妇的运动可能会改变后代的肠道微生物群多样性,需要进一步调查.
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