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Updated: May 14, 2025

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
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Published on: April 16, 2015

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拉格3和PD-1通路在早期CD4+ T细胞激活期间优先调节NFAT依赖的TCR信号程序

Lozan Sheriff1, Alastair Copland1, David A J Lecky1

  • 1Department of Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham B15 2TT, United Kingdom.

Immunotherapy advances
|May 12, 2025
PubMed
概括

Lag3和PD-1免疫检查点对早期CD4+T细胞激活进行控制. 组合阻塞增强了依赖NFAT的基因表达和T细胞受体信号持续时间,对免疫治疗具有翻译意义.

关键词:
CD4+ T 细胞是 CD4+ T 细胞.拉格3拉格3拉格3拉格在 NFAT NFAT 中.在PD-1中使用PD-1.在TCR信号传输中,这是一个宽容的宽容度.

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