在COVID-19疫苗的心血管后果
James N Nitz1, Kylie K Ruprecht1, Lukas J Henjum1
1Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, USA.
Cureus
|May 12, 2025
概括
COVID-19疫苗可以引起罕见的心血管不良事件,如心肌炎和VITT,尽管发病率很低. 长期风险在很大程度上尚未研究,目前的证据显示,对基线 CV 事件风险升高的支持有限.
科学领域:
- 心脏病学 心脏病学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- COVID-19疫苗至关重要但有争议,导致公众对副作用的审查.
- 了解心血管 (CV) 不良事件对于临床认可,公共卫生和未来研究至关重要.
研究的目的:
- 综合总结COVID-19疫苗对心血管的不良影响.
- 为临床实践和公共卫生战略提供有关疫苗安全的信息.
主要方法:
- 在2023年5月PubMed和Cochrane数据库的系统文献搜索.
- 从4419篇选的166篇文章中,包含了关于COVID-19疫苗CV并发症的数据.
- 报告的心血管不良事件及其发生率的审查和综合.
主要成果:
- 确定的不良事件包括心肌炎,心周炎,急性冠状动脉综合征,VITT和各种血栓性疾病.
- 肌心炎和疫苗诱导的血栓性血栓细胞缩 (VITT) 是最常被引用的.
- 报告的发生率:心肌炎 (2-17/百万),VITT (3-10/百万),CVST (2.6-10/百万),MI (3-4/百万).
结论:
- COVID-19疫苗与潜在的不良事件有关,主要是急性,发病率和严重程度低但显著.
- 副作用显示出人口和疫苗特定的模式.
- 有限的证据表明长期CV事件风险升高;超过六个月的研究很少.
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