基于CT的低骨肌量和质量的特定年龄和性别的参考值在健康的脏捐赠者中
David Martin1, Paola Dolce1, Martin Hübner1
1Department of Visceral Surgery, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
Frontiers in physiology
|May 12, 2025
概括
这项研究确定了健康成年人CT评估的骨肌肉标记物的特定年龄和性别的参考值. 这些值有助于识别有肌肉衰退风险的个体.
科学领域:
- 放射学 放射学是一门学科.
- 老年学是一门学科.
- 肌肉生理学 肌肉生理学
背景情况:
- 计算机断层扫描 (CT) 对于评估骨肌肉质量和质量是有价值的.
- 确定参考值对于解释基于CT的肌肉标志物至关重要.
研究的目的:
- 确定CT评估的骨肌肉标记物的特定年龄和性别的参考值.
- 将这些标记与血清肌素和24小时尿路肌素分泌 (24h-UCE) 相关联.
主要方法:
- 基于深度学习的CT分析骨肌肉指数 (SMI),骨肌肉辐射减弱 (SMRA) 和肌肉间脂肪组织指数 (IMATI) 在L3.
- 在394名健康个体中,以第五百分位数确定参考值.
- 皮尔森相关系数用于评估与肌素标记物的关系.
主要成果:
- 提供SMI,SMRA和IMATI的特定年龄和性别的参考值.
- 血清肌素与SMI的相关性中等 (r=0.452),与24小时UCE的相关性较弱 (r=0.188).
- SMRA和IMATI与两种肌素标记物都表现出较弱的相关性.
结论:
- 确定的特定年龄和性别的参考值在临床实践中适用.
- 这些值可以帮助识别患有与年龄有关的肌肉衰退风险的患者.
- 基于CT的肌肉标志物提供了超越传统肌素测量标准的肌肉健康洞察力.
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